|
KMID : 0545120160260010061
|
|
Journal of Microbiology and Biotechnology
2016 Volume.26 No. 1 p.61 ~ p.65
|
|
|
Anti-Thrombosis Activity of Sinapic Acid Isolated from the Lees of Bokbunja Wine
|
|
Kim Mi-Sun
Shin Woo-Chang
Kang Dong-Kyoon
Sohn Ho-Yong
|
|
|
Abstract
|
|
|
|
From the lees of bokbunja wine (LBW) made from Rubus coreanus Miquel, we have identified six compounds (1: trans-4-hydroxycinnamic acid; 2: trans-4-hydroxy-3-methoxycinnamic acid; 3: 3,4-dihydroxycinnamic acid; 4: 4-hydroxy-3-methoxybenzoic acid; 5: 3,5-dimethoxy-4- hydroxybenzoic acid; and 6: 3,5-dimethoxy-4-hydroxycinnamic acid (sinapic acid)) through silica gel chromatography and UHPLC-MS. The compounds 1-6 showed strong anticoagulation and platelet aggregation inhibitory activities without hemolytic effect against human red blood cells. To date, this is the first report of the in vitro anti-thrombosis activity of sinapic acid. Our results suggest that different cinnamic and benzoic acid derivatives are closely linked to the anti-thrombosis activity of LBW, and sinapic acid could be developed as a promising anti-thrombosis agent.
|
|
|
KEYWORD
|
|
|
Anti-thrombosis Activity, Sinapic Acid, lees of bokbunja wine, Rubus coreanus MIQ
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|